IL1A Protéine

N° du produit ABIN935485

Protéine Recombinant IL1A exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour IL1A Protéine (ABIN935485)

Antigène: IL1A (Interleukin 1 alpha (IL1A))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 98 % pure

Détail du produit

Séquence: SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA

Attributs du produit: Purified recombinant Human IL1 alpha protein
Expression System: E.coli
Bioactivity: The ED50 as determined by the dose-dependent stimulation of Mouse D10S cells is ? 0.001 ng/mL, corresponding to a specific activity of ? 1 x 10^9 units/mg.

niveau d'endotoxine: < 0.1 ng per µg (1 EU/µg).

Information d'application

Indications d'application: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute in water to a concentration of 0.1 - 1.0 mg/mL.

Buffer: Lyophilized from 10 mM tris, pH 8.0, with 50 mM NaCl.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: RT/-20 °C

Détail du antigène

Antigène: IL1A (Interleukin 1 alpha (IL1A))

Autre désignation: IL1 alpha

Sujet: IL1a is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL1a and IL1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL2 release, B-cell maturation and proliferation, mitogenic FGFlike activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL1beta is a secreted cytokine, IL1a is predominantly a cell-associated cytokine.
Alternative Names: Interleukin 1 alpha protein, Leukocyte Endogenous Mediator protein, MCF protein, EP protein, LAF protein, Hematopoietin-1 protein, Lymphocyte-activating factor protein, IL-1, IL1, IL-1 alpha protein, Mononuclear Cell Factor protein, Endogenous Pyrogen protein, IL 1 protein, LEM protein, IL 1, IL-1 protein

Poids moléculaire: 18 kDa

Pathways: Signalisation NF-kappaB, Autophagy, Cancer Immune Checkpoints